Sentence examples for the substantial difficulties from inspiring English sources

Much of the problem arises from the substantial difficulties that media faces in China.

The Dutch transport industry, like others in cities across the world, underestimated the substantial difficulties that they would face in forcing passengers to adopt a new payment system.

16 Classical approaches require twin and family samples, the availability of which is limited by the substantial difficulties and high costs inherent in their recruitment.

We use some approaches to prove the global existence-boundedness of classical solutions and overcome the substantial difficulty of the existence of a nonlinear prey-taxis term.

These results show the substantial difficulty associated with the aim of searching for all published cases.

A major drawback has been the substantial difficulty in designing HIF-specific inhibitors owing to the intracellular nature of the protein complex and the lack of active sites to which small molecular inhibitors are usually designed (Scheuermann et al., 2013).

However, considering the closed nature of the position, White faces substantial difficulties in the realisation of this nominal advantage".

In particular, the nonlocal structure of the fractional operators induce substantial difficulties in their analysis and significant dissimilarities in comparison with their integer-order counterparts.

While the problem of added predictive value has long been addressed in the literature for low-dimensional models, literature on added predictive value of signatures derived from high-dimensional data is scarce [ 11], although the high dimension of the predictor space adds substantial difficulties that have to be addressed by adapting classical methods.

Surveys in Australia, Canada, New Zealand, and the USA have suggested that over half the population may have substantial difficulties with reading and numeracy associated with health-related information and tasks [ 10– 10].

Any change or addition to the physics model would require a reformulation of the adjoint problem and substantial difficulties in its software implementation.