Exact(9)
The subsidiary analysis found 5535 trees of length 4262.625, using the same 4 1 weighting scheme of LEA (see Methods).
For the subsidiary analysis, species-level terminals were likewise synonymised to family-level, except that carnivorans and primates were synonymised to order-level, as in LEA.
As shown in Table 5, results obtained from the subsidiary analysis on the rescreened subset of MPP cohort were essentially consistent with the main findings.
On the other hand, the subsidiary analysis of the south Asian and black minorities compared with the white majority group of Whitehall II indicates that discrepancies are at least partly due to ethnic differences.
For the subsidiary analysis examining associations only with exposures in the nuclear family (death of siblings and parents of index offspring), we used the original sample (n=1 045 336); this sample may have also included those with missing links to grandparents in both exposed and unexposed cases (subsample 2).
For the subsidiary analysis (testing for commonality between so-called AS-neurotypical and HFA-neurotypical differences), we included data from an additional 57 male neurotypical participants from the control cohort of the MRC AIMS project (KCL n = 26, Cambridge n = 21, Oxford n = 10), that were matched in age and full-scale IQ with both ASC subgroups (with or without language delay).
Similar(51)
Once we removed diabetes and CHD, the results from this subsidiary analysis (with all five criteria measured) was very similar to the results using our primary approach (with ≥ three criteria measured).
For the differentially-weighted subsidiary analysis, we additionally computed DI values for each node, but solely for comparison with the values reported by LEA, given that the measure is not strictly valid in a supertree context.
Following my usual procedure, the formal prediction was set for all eggs, with a subsidiary analysis of the two eggs in India for comparison.
To further understand the "commonality" between subgroups, we performed a subsidiary analysis to test the spatial similarity between 2 VBM group-difference maps: 1) ASC with language delay versus neurotypical, 2) ASC without language delay versus neurotypical.
In addition to the main analysis, that will report treatment group effects for the primary outcome measure, a subsidiary analysis will use a multiple linear regression model to investigate the relationship between each patient's EQ-5D score at 12 months and the treatment arm, age, gender and dementia for each patient.
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