"It used to appear that there was only one answer, and a simple answer with not much nuance to it," said Dr. James C. Chatters, a forensic anthropologist who in 1996 was the first to study Kennewick Man, before further study was prohibited by the court proceedings.
As some of the cohorts in the D A D study are prohibited from collecting data on participants' ethnicity, the Cockroft-Gault (CG) formula was used [ 23- 25], standardized for body surface area (BSA), as has been done in a previous D A D analysis [ 2].
Sensitivity analyses with eGFR calculated from the MDRD or CKD-EPI equations [ 35, 36], were not carried out, as both of these methods required ethnicity, which some of the participating cohorts in the D A D study are prohibited from collecting.
There is no exclusion period during which participation in another study is prohibited, as soon as both protocols are compatible.
The use of immunosuppressant drugs, high-dose steroids and anti-TNF antibodies other than the study drug was prohibited during the study, as was administration of the study drug outside of the ICU.
Other exclusionary criteria included unsolved medical conditions, pregnancy and the use of medications known or suspected to affect fertility or metabolic function with 90 days of the study entry was prohibited.
Participation in any other form of psychological intervention for chronic pain in addition to the study intervention is prohibited during the trial.
Concomitant use of any antipsychotics other than the study drugs is prohibited (in case of need, concomitant use of 1 oral-dose drug is permitted at dose levels within the approved range, up to 4 doses in 4 weeks).
No patients were treated with granulocyte colony-stimulating factor because the medication was prohibited on the study.
Drugs other than the study medication (within 2 weeks prior to study start), usual consumption of >50 g alcohol per day, illicit drugs, and concomitant intake of alcohol, methylxanthines, or grapefruit products (72 h before first study drug administration until 48 h after last study drug administration) was prohibited.
