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The bioethicists had alleged, among other things, that the study was compromised by financial conflicts of interest and financial incentives to recruit and retain study participants.
Although the study was compromised by several limitations, our groups have shown that NRT may be associated with increased mortality in the critically ill [ 10].
The design of the study was compromised by responding to ethical concerns raised in the communities as well as by aid organizations regarding research conducted in the acute phase following a mass disaster.
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On the other hand, if individuals with low-risk behavior generally remain low-risk, the power of the study is compromised by including them in the trial.
Where a loss of significant quantities of participant data is reported such that the review authors agree that the conclusions of the study are compromised, trial authors will be contacted.
First, the generalizability of the study is compromised as a mathematical model was used to predict the cost, cost-effectiveness, and benefit for the three treatment alternatives (imatinib, sunitinib and palliative care).
Because of the heterogeneous surgical techniques and approaches, the comparability between the studies was compromised.
The accuracy of data extracted from the studies was compromised as we were unable to obtain numerical data from the authors.
However, as acknowledged by the authors, this study was compromised by the limited material available (Haynes and Heinly, 1995) and, thus, although the timing at which subsequent stages in T-cell development are first observed has been determined (Res and Spits, 1999), the stage at which the earliest hematopoietic cells colonize the human thymus remains unknown.
While the power of this study is compromised by the small sample size, the analysis did demonstrate a link between specific cytochrome p450 polymorphisms and an increased rate of TGCT development.
The New Zealand arm of the EMU study was compromised by damaging earthquakes to Canterbury which started in September 2010 and resulted in the premature end of recruitment, some disruption to birthplace choices and generalised stress and trauma for the whole community.
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