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Numerous post hoc analyses have been unable to prove or disprove causes; in fact, the design of the study renders such "proof" elusive.
Although the temporary association with the study renders the pulmonary emboli likely study drug related, a clear attribution to either vorinostat, doxorubicin, or the combination cannot be attained in the absence of a control arm without vorinostat.
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This allowed the investigators to maintain a constant gain throughout the study, rendering quantitative analysis of the waveform easier.
As a byproduct of including deaths, the prevalence of the primary outcome is increased, and thereby the power of the study, rendering the calculated trial size smaller than it might otherwise need to be.
We acknowledge that in day-to-day clinical practice, some of the patients would not have been managed with such aggressive titration of PEEP and therefore would not have received the levels of PEEP achieved in the study, rendering the clinical implications of these observations quite limited.
However, the low DA of the broad categories used in this study renders the observed average differences of little public health value as a solid basis for planning public health interventions in this area.
Although the conditions for the photochemical reduction of PtNPs were not optimized, the low LOD (approximately 1.6 μM) in this study renders the PEDOT-PtNP electrode attractive for the determination of H2O2.
In both included studies, more arthroscopic repairs were performed in the later years of the studies, rendering shorter follow up time in arthroscopically treated patients.
First, the retrospective nature of this study renders it at risk of bias.
Besides, the vast amount of imaging data that are acquired in population-based studies like the Rotterdam Study renders visual assessment or manual measurements virtually impossible, strengthening the need for (fully) automated methods of data extraction and analysis.
Together with the SBSA's theoretical link with Clark and Wells' (1995) model of social phobia, the findings of the current study render the SBSA an ideal research and clinical tool to assess the cognitions characteristic of social phobia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com