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The study fulfilled the requirements of the Declaration of Helsinki, and included an informed consent from the patients on admission (or their family if necessary) to participate and publish the results.
All patients in the study fulfilled criteria for severe sepsis or septic shock with a 30-day mortality of 20 % and initial mean arterial lactate of 3.3 (range 1.1 11.4) mmol/L in both experiments.
The two functional scoring outcomes evaluated in the study fulfilled their intended purpose to some extent; the CMPS-SF was designed using psychometric principles and is a spontaneous and evoked behavioral response scale for assessment of acute pain and need for further analgesic intervention.
In addition, number of organ failures included in the Sequential Organ Failure Assessment (SOFA) scale [28], date and time of inclusion into the study (fulfilled the criteria for severe sepsis), ICU and hospital length of stay, and ICU, hospital and 28-day mortality were recorded.
The study fulfilled Reporting Recommendations for Tumour Marker Prognostic Studies criteria for biomarkers.
The 56 SLE patients included in the study fulfilled four or more ACR classification criteria [ 24].
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We do not believe the Study fulfills the statutory mandate of Section 913 of the Dodd-Frank Act to evaluate the "effectiveness of existing legal or regulatory standards of care" applicable to broker-dealers and investment advisers..
The study fulfills the Declaration of Helsinki II.
None of the studies fulfilled all QUADAS criteria.
All the studies fulfilled the requirement of reporting basic statistical significance.
None of the studies fulfilled 50% or more of the internal validity criteria.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com