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Other aspects of his work include the proposal that changes in the structure of genes and in their regulation are important in the evolution of animals.
They have known the structure of genes, how they replicate, how they are controlled and expressed and, crucially, how to manipulate them.
Such technologies made it possible to examine the structure of genes directly by nucleotide sequencing, resulting in the confirmation of many of the inferences about genes originally made indirectly.
These new methods may provide a clearer picture of the difference between the structure of genes that are "on" and genes that are "off". As many cancers are driven by the abnormal expression of genes such as oncogenes and tumor suppressors, information about how DNA structure can turn genes on and off may aid in the development of cancer therapies.
Reporting directly to the provost, an Institute Professor defines the scope and extent of his or her responsibilities at MIT. Professor Sharp, head of the Department of Biology since 1991, shared the 1993 Nobel Prize in physiology or medicine for work that fundamentally changed scientists' understanding of the structure of genes.
Using shotgun metagenomic data from wild baboons, we found that social group membership and social network relationships predicted both the taxonomic structure of the gut microbiome and the structure of genes encoded by gut microbial species.
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Indeed, by having an initial set of periodic genes with a rich variety of signal types, pattern/shape information can be included in the study of systems and the generation of hypotheses regarding the structure of gene regulatory networks.
Close paralogues, particularly when tandemly arrayed, and subtle differences in the structure of gene models across multiple assemblies of the same genome sequence present significant challenges.
Genomic organization of the human PK superfamily and the structure of gene functional domains significantly differ from other protein coding genes.
To determine the structure of gene conversion events, DR- white.mu was created.
Several computational methods are currently used to learn the structure of gene-regulatory networks from data.
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