The strongest consistently replicated genetic risk factor for LOAD is the apolipoprotein E (APOE) gene.
The strongest, consistently replicated, genetic susceptibility factor is the major histocompatibility complex human leukocyte antigen dicloro-1-β-D-ribofuranosyl-benzimidazole 1 (HLantigen dicloro-1-β-D-ribofuranosyl-benzimidazole
Of the genes summarized on PDGene, the strongest, most consistently replicated associations are seen for GBA (glucosidase, beta, acid), LRRK2, SNCA, and MAPT (microtubule-associated protein tau).
The strongest and best replicated environmental risk factor for CD is smoking, which increases both the risk and severity of CD.
It is expected that 5-Aza has the strongest effect in replicating cells, when it gets incorporated as an analogue of deoxycytidine.
Of the remaining 5 genes, 4 did not have their strongest eQTL replicated in the gTEX database (p-value > 0.1) (RPL14, RPL14, XRN2, ALG11); only RPS26 occurred in both dura and blood and shared its most significant eQTL with the gTEX database.
Strong associations with seven genes were replicated in the Scandinavian samples and our approach effectively replicated the strongest previously known association in clefting with IRF6.
Logistic regression analysis showed that SNP G155391A was significantly associated with a high NPC risk in both sample groups (Data_GD2: P < 0.001, OR = 5.20, 95% CI 3.18 8.50; Data_GD3: P < 0.001, OR = 5.27, 95% CI 4.06 6.85; Table 4), indicating that the strong association was replicated in the two independent sample groups.
We have replicated the strongest association (rs9457951) in the Dallas Heart Study (DHS), and find a stronger effect after adjustment for the kringle(IV) CNV.
Our approach effectively replicated the strongest previously known association with cleft lip the one with IRF6 in both populations and by both methods, and suggested new associations with ADH1C and PDGFC.
