Having the hubs identified, we asked the question whether the strong connectivity occurs between genes involved in common or distinct biological processes.
The CS showed strong connectivity between certain TF-gene pairs including LFY → MYB17, LFY → TLP8, AP2 → HLH1, AP2 → RD20, AGL15 → AGL22, AGL15 → RAV2, HY5 → HLH1 and HY5 → RD20, among others.
The experimental results show that a large replicative capacity assures strong connectivity between self-replicating genotypes, making the system highly evolvable.
Although activity within both frontal clusters left BA 44/45 and 47/45 were highly correlated in the older group, only the latter was correlated with MTG activity, suggesting that although aging may weaken some frontotemporal connections, functionality is preserved by means of strong connectivity between functionally related regions.
Functional imaging studies from this group have provided evidence for hypoactivity in areas usually associated with action selection [e.g., supplementary motor area (SMA)], as well as abnormally strong connectivity between limbic structures (e.g., amygdala) and SMA [ 26, 28].
We also expected strong connectivity between hippocampus and perirhinal cortex/lateral occipital cortex to provide object information; however, our use of single-object baselines may preclude this being observed.
The age-dependent increase in activation that was observed in the ROI analysis appeared to be mainly driven by an increase for the expression task condition, possibly reflecting stronger connectivity between the FG and the amygdala in the adults.
The adolescent group showed stronger connectivity between arMPFC and pSTS/TPJ during social relative to basic emotion than did the adult group, suggestive of developmental changes in functional integration within the mentalising system.
Further, subjects in whom medial frontal regions acted as a stronger synchronization "hub" had stronger connectivity between the dipole source location and the corpus callosum and dorsomedial prefrontal white matter pathways.
Third, we explored the connectivity of the hippocampus during scene construction and scene perception, and found significantly stronger connectivity between anterior medial hippocampus and a distributed set of brain areas during scene construction compared with scene perception.
