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3) The stringency of data analyses needs to be increased.
Lowering the stringency of data selection criteria led to unrealistic estimates of promiscuity rates and their progression.
Thus, strong and validated disease signatures depend on the stringency of data analysis and comparison with apparently unrelated, publicly available data sets from other studies.
When the stringency of data selection criteria was gradually relaxed and low-confidence data were considered, unrealistic increases in promiscuity over time were detected.
When the stringency of data selection criteria was reduced in subsequent steps, non-realistic increases in promiscuity rates from ~6 targets per drug in 2000 to more than 28 targets were obtained.
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This shows that the stringency of the data representation provided with SVD is sufficient to infer Linnaean taxonomy levels.
Therefore, the stringency of activity data and compound selection decreased from the high-confidence set over low-confidence set 1 to low-confidence set 2. Progression of drug promiscuity over time was systematically evaluated on the basis of all three data sets.
This discrepancy was mainly due to differences in the stringency of the data-processing algorithm.
A potentially nasty conflict is growing between the U.S. and Europe over the stringency of Europe's data protection law the U.S. is pushing for industry self-regulation, while Europe wants legislation.
Regardless of the method and stringency of data filtering performed, the average expression of Z-linked contigs between males and females was essentially identical, suggesting the complete compensation of Z-linked genes.
Differences in stringency of data screening parameters, the taxonomic composition of databases used for the comparative analysis, and methods of phylogenetic analyses can significantly affect the outcome of the study.
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