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In the present review, we will discuss potential clinical and genetic limitations intrinsic to the strategies using a diagnostic phenotype.
In addition, the exclusion of such information did not alter the potential population impact of the strategies using routine data for prestratification.
The base case analysis estimated the ICURs between the strategies using point estimates of the parameters (i.e., weighted-average from the meta-analysis).
Comparison of Figure 2a and b shows that, in general, the strategies using profiles from SUPERFAMILY perform better than those using Pfam profiles.
Finally, excluding family history of diabetes, smoking, or body mass index from the Cambridge risk score did not significantly reduce the population impact of the strategies using routine data as a prestratification tool.
Lastly, excluding family history of diabetes, smoking and/or BMI from the CRS did not significantly reduce the population impact of the strategies using routine data as a prestratification tool.
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