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The stage shift was accompanied by a significant increase in the surgical resection rate.
If so, this surge of cases would fall back to a 'steady state' with the expectation that, if awareness efforts were reinforced and effective over time, the stage shift would also be maintained.
If we assume that the stage distribution for different screening scenarios in Catalonia is similar to the US distribution (which is consistent with most of the RCT results, 70-80% of early diagnosed cases which are node negative), then the stage shift attributable to screening would have been even higher in Catalonia, resulting in a larger effect of early detection.
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Instead of hearty, long-simmered ragus and dense tomato and game sauces the stage shifts to sheer, herbaceous mixtures that cling lightly to strands of fresh fettuccine, slender tagliarini or penne.
However, the increasing trend of invasive breast cancers in the south of Switzerland, together with the stage shifting described above, along with tumour diameter decrease and in situ cancer increase, seems to be because of a progressive increase in the use of early detection diagnostics.
By examining the stage-shifts in mammographic screening trials, and the fatality rates by stage, one can derive estimates of which cancers detected at screening save most lives.
"It's like the ultimate stage shift," Dr. Hawk said of the new results.
This paper, therefore, examines whether a cancer detected by mammographic screening confers additional prognostic benefit to the patient over and above that expected by the improved stage shift.
The aim was to identify whether this was solely due to the earlier stage shift of these cancers, or whether other factors were involved.
The downward stage shift observed in southern Switzerland was accompanied by a decreasing trend of invasive tumour size at the time of diagnosis.
At six months, 27 (49%) of these smokers had made at least one quit attempt lasting 24 hours or more but the mean stage shift from baseline stage of change was zero.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com