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We present the first crystal structures of Fcabs, i.e., of the HER2-binding clone H10-03-6 hABing the andand EF loop engineered and the stabilized version STAB19 derived by directed evolution.
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The elastic net is a stabilized version of the Lasso; it encourages groups of correlated variables to enter the model together, and thus a small change in the data will not have a large effect on the model.
Consistently, ubiquitous repression of auxin responses by expressing a stabilized version of the auxin response inhibitor PttIAA3 reduces the number of cell divisions in the cambium region of hybrid aspen trees18.
pG60 is a stabilized version of the prodomain used in previous studies (19).
The special case of S^3gives back a stabilized version of knot Floer homology.
As a proof of principle, we designed rigid fusions of a stabilized version of Escherichia coli TEM-1 β-lactamase to the C-terminal capping repeat of various DARPins in six different relative domain orientations.
Another difficulty in implementing IPTW methodology is that estimated weights (even when using their "stabilized" version) may be highly skewed by a few individuals with extreme values, requiring additional sensitivity analyses [ 4].
The latest stabilized versions of Hadoop, release 1.2.1 and Hive version 0.12.0 are used [1],[1]].
In human cancers, besides the deregulated expression of MYC, stabilized versions of Myc act as main reasons for malignant transformation and cancer progression (Junttila and Westermarck, 2008).
Ectopic expression of PpJAZ1 in tobacco led to JA-insensitivity similar to that obtained after expressing stabilized versions of Arabidopsis JAZ1, JAZ3 or JAZ10, which lack Jas motifs (JAZΔJas), except that transgenic PpJAZ1 plants are generally fertile.
Just as in the construct optimization process, point mutation screening could identify a more stabilizing version of the protein (Zhang et al., 2014).
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