The choice of detergent to solubilize a membrane protein from its lipid membrane may be tricky, since it affects the structure, stabilization, and function of the target protein.
The importance of plakophilin-2 as a kind of "organizer" protein in the formation, stabilization and functions of the AC structure and the ID architecture is discussed in relation to other junction proteins and to causes of certain cardiomyopathies.
For instance, there is evidence that cleavage of PS and formation of heterodimeric PS NTFs and CTFs complexes is required for complete stabilization and function of PS/γ-secretase [24], [27], [56].
Proteasome-induced cytotoxicity could potentially result from multiple events, including the stabilization and deregulated function of cyclins, cell-cycle-dependent kinase inhibitors, tumor suppressor proteins, IκB, proapoptotic proteins, and a large number of other proteins associated with cell cycle progression[ 14].
Clustering of 2'- O-methylations in the functional important and evolutionary conserved regions suggests that these modifications contribute to the folding, structural stabilization, assembly and function of the 23S rRNA within the large subunit of the ribosome.
Nanocarriers can fulfill essential functions in the stabilization and delivery of drugs: they prevent solubility issues and degradation, reduce side effects and modify the pharmacokinetic profile.
The possible mechanisms behind HIF1α stabilization and the function of cytoplasmic HIF1α in NE cells of benign and malignant prostate tissues are not known.
Considering the profound requirement of NGF for nonpeptidergic nociceptor gene expression, one possibility is that NGF promotes expression of Runx1, Cbfb, or both, thereby enabling Runx1/CBFβ complex formation, stabilization and function, and thus initiation of the nonpeptidergic nociceptor fate.
ABAD/HSD10 may also be important in the stabilization of mitochondrial function [ 14] and in the maintenance of normal functions of GABAergic neurons [ 11].
