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The spread of isolates carrying blaCTX-M-15 in China warrants more studies.
Continued surveillance of gonococcal antimicrobial susceptibilities is vital to inform treatment guidelines and mitigate the spread of isolates with decreased susceptibility to cephalosporins and resistance to azithromycin.
In Taiwan, one pilot study described the spread of isolates with blaOXA-72, a member of the blaOXA-24 family, within a single medical center [ 13].
The introduction of conjugate vaccines, which have an impact on carriage and transmission of the bacteria, could reduce the spread of isolates from asymptomatic pilgrims to their household contacts upon returning from the pilgrimage [ 6, 14].
Previously, it was reported in Taiwan that the CCs related to Spain23F-1, Tandan19F-14, and Taiwan23F-15 weresponsibleble for the spread of isolates with high-beta-lactam resistance [ 24, 25].
Although causality cannot be attributed to this decline, the higher dose of ceftriaxone plus azithromycin could be more effectively treating gonococcal infections and diminishing the spread of isolates with reduced cephalosporin susceptibility.
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Therefore, identification of further alleles with different resistance specificity should have value, by broadening the range of resistance genes available to breeders and thus delaying the spread of virulent isolates.
Strategies are needed to limit the spread of such isolates.
After identifying the source of the contamination, appropriate control measures should be implemented in the affected countries to control the spread of these isolates.
Our finding of a relatively novel spoligotype of M. tuberculosis in an animal destined for the pet trade underscores the need for intensive testing of and extended quarantine for all imported nonhuman primates to prevent the spread of newly isolated M. tuberculosis (4, 7, 8 ).
Rapid and specific detection of extended-spectrum β-lactamase-producing (ESBL) bacteria is crucial both for timely antibiotic therapy when treating infected patients as well as for appropriate infection control measures aimed at curbing the spread of ESBL-producing isolates.
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