111 In a phase I study in advanced or refractory NHL, pixantrone was tolerable at doses associated with antitumor activity, with grade 4 neutropenia as the sole dose-limiting toxicity.
The aim of this work was to study soil particle aggregation of a semiarid, degraded soil 5 years after the addition of a sole dose (120 Mg ha− 1) of non-composted (SS) and composted sewage sludge (cSS).
This retrospective cohort study compared the efficacy of interstitial high dose rate brachytherapy (HDR-BRT), re-resection and sole dose dense temozolomide chemotherapy (ddTMZ) in the treatment of recurrent glioblastoma after initial surgery and radiochemotherapy.
Our studies are the first direct demonstration that radiation-triggered cell death is susceptible to the energy of the individual photons from an electromagnetic radiation source, such as X-ray, rather than the sole total dose absorbed by the system.
However, a retrospective review of 60 phase I trials of targeted agents reported mainly between 1999 and 2002 revealed that the majority of studies had used toxicity as the sole determinant for dose selection in phase II studies.
Among MA dUCBT recipients, CD3+ cell dose remained the sole independent predictor of the predominant unit (OR 4.4, 95%CI, 1.8 10.6, p<0.01) with a larger dose more likely predominating.
If reduction in unnecessary cardiac dosing were the sole concern, then 'mini-tangent' conventional beams avoiding the lower breast pole or incorporation of cardiac beam shaping would achieve the objective in upper pole cancers very simply [ 9].
Intravenous golimumab safety findings, including the occurrence of infusion reactions and serious infections, reported here were consistent with those observed in patients with active RA despite prior MTX therapy for whom subcutaneous dosing was the sole route of golimumab administration.
The logistic regression analysis indicates that the use of high dose TGC was the sole independent predictor of clinical cure (OR 6.25, 95% CI 1.59, 24.57), instead a higher SOFA score (OR 0.66, 95% CI 0.51, 0.87), and IIAT (OR 0.18, 95% CI 0.05, 0.68) was significantly associated with clinical failure (Table 3).
Thus, antigen dose appears to not be the sole determinant of increased efficacy in our tolerance induction platform.
Her first partouze earns her a dose of the clap, but that's the sole mention of sexually transmitted disease.
