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Mr. Koizumi rose to prominence in the 1996 party presidential election by mounting the sole challenge to Mr. Hashimoto, who eventually won in a landslide.
The absence of an appropriate framework from which to examine homeopathic remedies is one but not the sole challenge to quality research in this alternative practice.
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Only John Kasich remains as Trump's sole challenge to the Republican nomination.
Since September 11th 2001, and the rise of radical Islam as the sole violent challenge to an American-shaped international order, America's focus on the region between the Nile and the Indus rivers has been obsessive.
As worsening Sino-Japanese relations attest, North Korea is far from being the sole security challenge in this area.
The sole successful legal challenge concerned the way in which the property compensation consultation for HS2 had been carried out.
However, the choice of Schu S4 as a "fully virulent" strain and as the sole type A challenge strain in murine models that evaluate the efficacy of human vaccine and therapeutics against F. tularensis infection, should be reconsidered.
While many earlier studies have stressed the influence of altered pattern of shear stress on atherogenesis (Bassiouny et al. 1992; Ku et al. 1985), some other investigations have challenged the sole role of shear stress pattern in situations such as intimal thickening in the right coronary (Joshi et al. 2004) and carotid bifurcation (Steinman et al. 2002).
You were the person, the sole significant leader who challenged the Democratic Party to produce a candidate to run against Hillary Clinton.
Just as public health challenges can no longer be effectively addressed only within the health sector and at the national level, the WHO can no longer be the sole manager of intergovernmental challenges relating to the governance of global health.
When he reconvened the band in 2007 (though he was soon the sole original member), he resumed challenging its audience.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com