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Mathematical modelling can only go so far, in the end testing is needed in the real world (beyond the small trials such as the one at Longannet which tested the capture bit which have already been done).
The small trials were more likely to show a benefit for hydration with sodium bicarbonate, but these studies were generally of lower methodological quality.
Average group sizes were 100, 250, 500 or 1000 subjects, and the large trials had 10 times more subjects than the small trials.
The small trials by Mottola et al. [ 25] and Hui et al [ 26] showed promising results in preventing GDM with nutrition and physical activity modification.
Furthermore, the small trials were of low quality in methodology compared with large trials, which may partly account for the small-study effects.
Intention-to-treat analysis was used in 83% of the large trials, while only 52% of the small trials used this analysis (P <0.001).
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So the question is, what to do next the small trial.
It also began to sell the drug based on the small trial.
The small trial in Baltimore was pivotal, and not only for the young marketing professional.
New Scientist reports that the small trial aimed to correct two genetic conditions in six otherwise normal embryos.
The drug, developed by Biogen Idec, could achieve sales of billions of dollars a year if the results from the small trial are replicated in larger trials.
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