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In the example presented in Figure 7, sigmaf increased from 3 ms to 12 ms for the fast compound EPSC (τrise/τdecay 0.3/3 ms; Figure 7A), and from 16 ms to 32 ms for the slow compound EPSC (τrise/τdecay 5/50 ms; Figure 7B).
Changing the compound EPSC amplitude of fast EPSCs (τrise/τdecay 0.1/1 ms) had a much stronger effect on STP than amplitude changes for slow EPSCs: to increment STP by 50%, the fast compound EPSC amplitude had to be increased by only 5%, but the slow compound EPSC by as much as 40%.
However, calculating the charge delivered for each compound EPSC at spike threshold showed that the slow compound EPSC (τrise/τdecay 5/50 ms) contained the highest charge (total: mean = 23.38, s.e.m. = 0.27 nC; at threshold: mean = 10.045, s.e.m. = 0.06 nC), and that charge was gradually reduced for faster compounds (Figure 3F).
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This led to J.R. Hildebrand suffering a one lap penalty as his car required repair work, and a number of drivers being angered at having to stay on the harder tires, which were the slower compound.
If the problem is solved as purely coplanar, a slow compound wave appears in the self-similar solution obtained by any shock-capturing scheme.
The difference in STP between fast and slow compound EPSCs could be reduced by incrementing the amplitude of slow compound EPSCs.
This suggests that, given the proper amplitude, both fast and slow compound EPSCs can produce temporally precise spike responses, but responses to fast EPSCs are much more sensitive to changes in EPSC amplitude, e.g. due to plastic changes in synaptic strength.
Finally, we investigated the effect of synaptic noise on sigmaf for fast and slow compound EPSCs (Figure 7).
We found a significant difference between fast and slow compound EPSCs in their ability to reliably elicit spikes in the presences of input jitter.
By contrast, slow compound EPSCs reliably propagate signals that are less well synchronized but with more variability in spike timing.
As previously described, slow compound EPSCs (τrise/τdecay 5/50 ms) induced spikes with low temporal precision at threshold amplitude.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com