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The results show that the peak normal stresses on a square model are the largest among all the models tested, the setback model shows the smallest peak normal stresses of the single modification models tested, and CC+TP+360Hel shows the smallest peak normal stresses of the multiple modification models tested.
There was no difference in the level and distribution of the single modification between undifferentiated and differentiated mesenchymal stem cells.
It is interesting to note that the single modification at the Lys residue determines the apoptotic or survival fate of cancer cells.
In the case of modification we have examined the importance of individual features by removing the single modification from the feature set.
When the cells were differentiated, it was no longer possible to detect significant levels of the single modification and this was mirrored by the increase in the level of the double modification.
HeLa cells were also synchronized using the double-thymidine block protocol described in Section 6.1 with the single modification that 1 μM DMSO or 1 μM TSA in DMSO were added in addition to the 2 mM thymidine at 30 h (Fig. 17, lanes 3 and 4 right).
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Furthermore, the complexity of post-translational modifications of p53 needs to be taken into consideration to reveal the functional significance of the single modifications as well as the sequential interplay of different modifications [38].
The lower level of the H3K9me3 single modification that was observed by immunostaining of plasma cells compared with the level measured by western blotting could be due to reduced accessibility of the modification to intracellular antibody staining, suggesting that it may be located within the heterochromatin mass.
For comparison between peptides with combinatorial modifications, the intensities were normalized to the peptide with single modification as log2 ratio.
The ultimate biodegradability of the studied HILs was evaluated based on the OECD 301 F test (manometric respirometry), which was conducted with a single modification: the tests were carried out with the use of microbiota previously isolated from environmental niches (as described in 2.4.1) instead of the routinely applied activated sludge.
Histone modifications: Again, epigenetic regulation can be understood not as the consequence of a single modification (e.g., CpG methylation), but rather as the product of several epigenetic factors working in concert.
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