The single dose-response curves for drugs A i,i=1,2,3 are assumed to be f i (x i )=α i +β log(x i ),i=1,2,3.
For a numerical illustration we consider L Y−168 from (Tian et al. 2009) which is said to be a potential anti melanoma agent and has the single dose-response curve f 1(x 1)=101.91−31.17x 1.L Y−168 will be considered with Sorafenib which is marketed as Nevaxar by Bayer for the treatment of advanced renal cell cancer and also of advanced thyroid cancer in the USA.
Rather than considering a chemical as having a single dose response curve for toxicity, chemicals appear to have different dose response curves depending on the life stage at which exposure occurs.
It is possible that the variances in behavior between carbachol and isoprenaline are accounted for by differences in the relative position of the single dose on the dose-response curve.
Immune responses after the single dose of PPSV23 showed that responses were generally maintained compared with responses after the last dose of PCV13.
In this analysis we used only 50 replicates of the NF-кB system because of the high computational cost of calculating a single dose-response curve.
There can be substantial strain-to-strain variability within a species or serotype, making it difficult to collect the basic data needed to generate a single dose-response curve for that pathogen (FDA/FSIS, 2003).
Given that the difference between the individual NLRs of GNT-S Plough does not reach significance, all the data belong to the same population and therefore are better described by a single dose-response curve, i.e., a significantly more robust and reliable NLR.
These values from each single dose-response curve were averaged thereafter.
23 If a study reported categorical estimates only, they were combined to obtain a single dose-response estimate.
Translating the idea of "minimal lifetime" into a mathematical model leads to a product of the two single compound dose response curves modeled by Eq. (1) as non-synergistic combined effect (Fig. 1b, blue curve); this concept is compatible with Bliss independence.
