Sentence examples for the single alterations from inspiring English sources
Altering PTEN in combination with either p53 or EGFR in contrast to any of the single alterations caused increased growth of transformed colonies in soft agar.
Less work has examined the impact of single alterations in the timing of the LD cycle [34], even though these phase shifts disrupt the rhythms in clock gene expression within the SCN [35], [36] and between the SCN and peripheral oscillators [37].
These variants are considered benign and may be polymorphisms as the single base alterations do not lead to amino acid substitutions (L625L and P977P) and are unlikely to be potential splice site variants.
The single genetic alterations were not retained in the model.
Thus, the single genetic alterations could be considered as surrogate markers for an underlying abnormality, which will confer additional selective advantage to tumour cells.
However, the single chromosome alterations 1p loss, 2p gain, 3p loss, 4p loss, 11q loss and 17q and a SCA genomic profile were observed more frequently in infants with radiologically confirmed bone metastases compared with those without bone lesions (χ-test, P<0.0001; Table 1).
Isolates with single alterations in gyrA83 exhibited reduced susceptibility to ciprofloxacin (MIC = 0.5 2 μg/mL).
Some alterations were found to occur as single alterations, while others were only recognized in tumours with several other changes.
When cells expressing different single alterations were compared for their ability to grow, we observed distinct differences in their proliferation capacity.
In some cases, the presence of a single alteration dictates the use of a specific drug such as all-trans-retinoic acid for t(15 17) positive acute promyelocytic leukemia or an ABL1 tyrosine kinase inhibitor for t(9 22) positive chronic myelogenous leukemia (CML).
Researchers from Massachusetts General Hospital MGH Cancer Centerer and colleagues in France describe in the January 2 edition of the Journal of the American Medical Association that a single alteration in the epidermal growth factor (EFG) gene may greatly increase the risk of developing HCC.
