Sentence examples for the significant drawback from inspiring English sources

Although ground-coupled heat pump (GCHP) systems are becoming attractive air-conditioning systems in some regions, the significant drawback for their wider application is the high initial cost.

While metacarpal lengthening via distraction osteogenesis can achieve a mean elongation of 3.5 cm, it bears the significant drawback that the full treatment lasts several months with continuous application of the external fixator [9].

In addition, all substrates suffer from the significant drawback that they generally lack selectivity.

The significant drawback of injectable liquid silicone is that the product and the respective reactive tissue cannot be removed without consequent deformity.

Using computers means higher uniqueness of data feeding, of term definitions, their precise denomination, etc., thereby the significant drawback becomes more noticeable.

Solubility of ARTM in water is poor, so it has been synthesized in tablets as well as intramuscular injections, but short half-life of about 3 to 5 hours is the significant drawback of ARTM [ 7].

One of the significant drawbacks of freight by rail is its lack of door-to-door capability.

The significant drawbacks and lack of success associated with current methods to treat critically sized nerve defects have led to increased interest in neural tissue engineering.

Hence, although both practices offer regular flexibility, employees prefer flexible work schedules to telecommuting, because flexible work schedules provide daily working time flexibility without the significant drawbacks of telecommuting.

The local economy is strongly dependent on the primary sector, despite a certain shift of workforce towards the secondary and tertiary sector and the significant drawbacks of primary production, such as the small scale land properties, the ageing of workforce, and the lagging behind as to the technological modernization, innovation etc. sector [25].

On the other hand, one of the significant drawbacks to the use of KLH as a TAAs carrier in antitumour vaccines is their poor solubility and propensity to aggregate and precipitate (Gathuru et al, 2005).