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The Wnt pathway was assessed by beta catenin levels and the SHH pathway by SHH levels.
What colour is Mr Tickle, what the – shh, keep your voices down!
Abnormal activation of the SHH pathway has been reported in a number of CSC models [84].
The SHH + Cort group (n = 2) was treated with Hydrocortisone and hyper-fluid therapy.
This is consistent with the predicted role of Gli3 as a repressor of the Shh response.
Glioma-associated oncogene homolog 1 (Gli1) and patched-1 (Ptch1) are both components and transcriptional targets of the Shh pathway.
Similar(5)
We have engineered the Shh-Fc fusion protein in order to improve binding affinity and increase systemic exposure in animals.
YY performed some of the shh-injection experiments.
The Shh-induced vessels showed a characteristically large diameter.
Mice homozygous for the Shh-null allele were as published.
10.7554/eLife.02555.019 Figure 8. Smurfs are required for the Shh-induced endocytic turnover of Ptch1.
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