Sentence examples for the shared target from inspiring English sources
The resulting data show a strikingly similar binding pattern of MP, BRM and SYD at the shared target loci, which is unlikely to be coincidental.
To evaluate the significance of the shared target genes, we apply the hypergeometric test for ranked lists of a TF's target genes.
The shared target preference of Tx1-Mar and SINEU strongly suggest that SINEU families are mobilized by the machinery of Tx1-Mar non-LTR retrotransposons.
As expected, the positive drug pairs seemed to be helpful for predicting new targets (e.g. α1 of Motilium, α2 of Xenazine and δ of prantal) by annotation transfer based on the shared target.
Thus, in our system, while disrupting both PuF and SP1 activity by primary sequence mutation may result in overall reduction in reporter levels, environmentally-induced epigenetic alterations to the shared target DNA sequence may favor SP1 stimulation over PuF inhibition.
We measure the similarity of these ranked lists for all possible pairs (130 * 129/2 = 8385) of TFs by calculation of the significance for the shared target genes among the top- L1 (for the first TF) and the top- L2 (for the second TF) ranked genes using the hypergeometric test [ 18].
The links between drugs are obtained by quantifying molecular similarity with chemical fingerprints and examining the shared targets.
Another possibility is that 5HT and DA have opposite actions on certain of the shared targets, and changing the function of both amines simultaneously yields a phenotype different from the one obtained by manipulating each of the amines alone.
The shared targets are all directly concerned with motility, whereas retrograde transport genes are not Foxj1 targets in vertebrates.
In that case, one can still intersect the data from different experiments to obtain a putative target gene set assumed to contain the shared targets.
It will be interesting in future work to determine whether the shared targets of these two pathways affect phenotypes beyond the circadian system.
