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The fundamental principle in regulatory toxicology is that all chemicals are toxic and that the severity of effect is proportional to the exposure level.
Categories are loosely ordered by the severity of effect, with LoF annotations listed before nonsynonymous, synonymous, non-exonic categories and so on.
Accounting for the severity of effect for such data is a major challenge, for example, using a TEL/BMR concept or perhaps requiring development of multivariate/multidimensional extensions thereof.
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The EX distance is based on experimental assays of the severity-of-effect of amino acid substitutions on protein function and was specifically designed to reflect functional differences in amino acid sequences while being free of mutational bias.
The severity of effects can go from 0-10 very quickly".
The severity of effects can go from zero to ten very quickly".
The severity of effects differs depending on the particular scenario, but the undeniable fact is that nuclear war poses a grave and present danger to our planet.
"If a lapse occurs, the severity of effects would grow quickly if it turns out to be long," he said.
Moreover, experiments using overexpression of several genes in different regions of the Drosophila wing found an association between the severity of effects and levels of FA [31].
Consistent with previous reports, we find that approximately 40% of cells treated with the GSK3 inhibitor SB-216763 exhibited misaligned chromosomes [3], [5], very similar to the severity of effects observed with CRMP4 loss of function (Fig. 2C).
The severity of effects increases with the dose.
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CEO of Professional Science Editing for Scientists @ prosciediting.com