Maternal pre-immunition has been considered crucial for the disease severity, however hormonal changes and immuno-depression could have an important contribution to the observed increased susceptibility to infection during pregnancy [42] [46].
The average severity, however, will be less following treatment, because for all patients studied, their disease severity at treatment entry will have been high.
It may be related to the disease severity; however, patient 2-II-1 showed comparable peripheral RNFL thickness and better BCVA compared to the other ADOA patients without MME.
Repeated-measures analysis of variance (ANOVA) indicates that there were significant differences (P < 0.01) among genotypes in all inoculations for GLS severity; however, the differences were not significant between the inoculations within the same leaf age (Table 3a).
Our results suggest that allelic heterogeneity might influence penetrance and severity; however, the high variability of these phenotypes tempers the confidence of this conclusion.
The plots illustrate that the expected values generated from the statistical model fit the data extremely closely across the entire range of disease severity, however severity is defined.
No predominant serotype was identified by farm or by systemic disease severity; however, the most frequent serotype, O158 NM (n = 3), was isolated from cows in the moderate severity group.
Supporting this are data suggesting children with pain-related FGIDs who had more anxiety and somatization also had increased pain frequency and severity; however, the study did not measure visceral sensitivity [15].
Intravitreal anti vascular endothelial growth factor (VEGF) agents have proved effective to treat diabetic macular edema and reduce diabetic retinopathy severity; however, the durability of these agents is limited by a short half-life in the vitreous.
The factors influencing infection severity, however, are not fully understood.
PM declines in proportion with disease severity; however, the protein component of FFM may be rapidly replenished after weight regain.
