Moreover, among the strains that did elicit diarrhea, the severity and range of symptoms sometimes varied widely.
Despite years of intense study, determining the developmental basis for the enormous variation in both the severity and range of birth defects linked to prenatal alcohol exposure remains a formidable challenge.
In this study, Joseph Buxbaum and colleagues sought to determine whether modifier loci affect the severity and range of autistic behaviours and developmental deficits associated with the genetic disorder Phelan-McDermid syndrome (PMS).
The general consensus is that the differences in severity and range of PMS symptoms are due to variation at a number of gene loci (Condon 1993; Kendler et al. 1998; Treloar et al. 2002).
Thus, the epigenetic errors resulting from alcohol exposure can vary greatly depending on the specific timing and dose of alcohol exposure, which can explain the wide diversity in severity and range of birth defects that characterize FASD (Becker et al. 1996).
Lateral flows can be intercepted by filters and thus the severity and spatial range of external effects of land use change is under the influence of filter effects.
The present study sought to assess patient perceptions of the severity and importance of a range of symptoms and their personal impact, and their expectation of improvement from the proposed therapy for those symptoms.
Starting in the mid-1990s, the frequency, severity, and geographic range of WNV outbreaks increased, and outbreaks of WNV meningitis and encephalitis affecting primarily adults struck Bucharest, Romania, in 1996, Volgograd, Russia, in 1999, and Israel, in 2000 [ 14– 16].
Tools varied in the number and range of severity levels assessed.
Across the spectrum of AAV, disease is sub-classified according to the severity and extent of organ involvement, ranging from localised to severe organ-threatening or life-threatening disease [ 6] (Table 2).
Unlike any other Charcot Marie Tooth disease-linked gene, the various identified mutations in GDAP1 are associated with demyelinating, axonal, or mixed forms of Charcot Marie Tooth disease with recessive or dominant modes of inheritance, showing a wide range in the severity and onset of disease (Cassereau et al., 2011 a, b ).
