Another approach to enhancing specificity would be to focus surveillance on the severe phases of disease, since the category A bioterrorism infections are more likely than many common infections to progress to life-threatening illness.
There were fears of another event like Lehman, the American investment bank whose failure in 2008 led to the most severe phase of the international financial crisis.
Citing the debt reductions that Congress undertook in 1937 and that ushered in the most severe phase of the Great Depression, some economists fear that imposing austerity measures too soon could likewise result in a recessionary relapse.
To test the hypothesis that cytokine signal transduction is modulated in both pathway- and cell-specific manners that correlate with SLE disease status, we analyzed samples collected before disease onset through initiation to the terminally severe phase using the MRL/lpr murine model of SLE.
This suggested that antiviral therapies may help to control the disease progression in the extremely severe phase.
Also, the expression of TGF-β1 directly at the cartilage-pannus junction during the most severe phase of rat collagen-induced arthritis [ 23] suggests TGF-β1 has an important pro-destructive role in experimental arthritis.
Median clinicopathologic blood values were calculated among PIV seroconversion cases by using the serum sample with the highest leukocyte count from each identified animal (e.g., the blood sample most likely representing the most severe phase of disease).
In previous trials, frovatriptan was able to decrease the overall duration of migraine attacks significantly [19], and it is more efficacious when taken during the mild, beginning phase of a migraine attack versus taken during the later severe phase [20].
This profile was carried out over a 15 week period to map changes in signaling that occurred as the mice transited from a pre-disease state, through early and intermediate stages, to the terminally severe phase of SLE.
Together, BACE1+/− gene deletion was able to more specifically improve memory dysfunction in 5XFAD mice; however, the memory benefit produced by partial reduction of BACE1 was observed in an age-related manner and disappeared as disease progressed into the more severe phase in 5XFAD mice.
