Sentence examples for the severe involvement from inspiring English sources

The marked impairment of overall autonomic reactivity in SD here is consistent particularly with the severe involvement of central autonomic network hubs in amygdala and insula in this syndrome [23], [28].

A striking and consistent phenotype characterized by maintenance of the ability to walk (with head and trunk support) despite subgravity upper limb and neck strength was observed in all but one patient in this cohort, resulting from the comparatively milder lower limb weakness in contrast to the severe involvement of axial and upper limb muscles (Fig. 3).

These observations confirmed the importance of the more severe involvement of the thenar muscle in patients with ALS.

Supportive to this thought was the finding of Braak et al. in 1991, that in all limbic nuclei of the thalamus extracellular amyloid deposits and neurofibrillary tangles occur, although the most severe involvement was found in the medial-dorsal nucleus (Braak and Braak, 1991).

In our patient, with asymptomatic WM, the peripheral retinal hemorrhages were associated with an extensive area of capillary non-perfusion, in the absence of severe involvement of the posterior pole; this association to the best of our knowledge has never been reported before.

In our patient with WM an extensive area of capillary non-perfusion, in the absence of severe involvement of the posterior pole was documented; this association to the best of our knowledge has never been reported before.

Semiquantitative analysis of infiltrate was also performed, and inflammatory infiltrate was classified as follows: mild (involvement > 25% of the tissue), moderate (25%50%% of the tissue), or severe (involvement > 50% of the tissue).

Despite intrafamilial differences in severity of the phenotype, all reported cases of EDM2 in addition to our cases have shared the features of more severe involvement of the knees and relative sparing of the hips (Barrie et al.1958, van Mourik et al. 1998, Holden et al. 1999, Fiedler et al. 2002).

These include a systematic hierarchical spread of disease upwards and downwards in the neuraxis from the medulla, a strong association between amygdala-predominant AS and Alzheimer's disease, and the expectation that more severe involvement of the cerebral cortex is correlated with increasing risk of dementia [ 2, 25- 29, 31, 33- 37].

Lesions were graded on a scale from 0 to 4: 0 = normal; 1 = mild, involvement of less than 25% of the cortex; 2 = moderate, involvement of 25% to 50% of the cortex; 3 = severe, involvement of 50 to 75% of the cortex; 4 = extensive damage involving more than 75% of the cortex.

In cases like those involving the internal condyle of the knee, where there is osteonecrosis with severe involvement of the subchondral bone, autologous osteochondral grafts are performed.