Exact(5)
Both the captive population of red wolves and the captive population of Mexican wolves show low levels of genetic diversity, which is to be expected given the severe bottleneck imposed by limited numbers of founders and subsequent captive breeding (in total 7 founders for the three lineages involved in the Mexican wolf captive breeding program, 14 founders for the captive red wolves [45]).
Conversely, given the much larger difference in estimated current population sizes, combined with the severe bottleneck estimated in D. miranda, polymorphism-based estimates of selection may differ more dramatically between species.
The increased variance created by the severe bottleneck in D. miranda is elevating the estimated rate of adaptive evolution somewhat, whereas the variance reducing effect of population growth in D. pseudoobscura is resulting in a slight underestimate.
The heritage variety BvSW showed the lowest heterozygosity of all turkey populations, which is consistent with the severe bottleneck that this population went through in 2000 (Alexandra Scupham, Personal communications).
In particular, if transmission is neutral it can be concluded from the severe bottleneck reported here that the consequent genetic drift will be strong, with negative consequences for viral fitness.
Similar(55)
Despite this severe bottleneck, however, there is strong heterogeneity in the retention of polymorphism at different loci in C. rubella[ 28, 31].
However, it is also possible that the less severe bottleneck in the harsh condition, which decreased extinction probabilities (see previous section), acted to negate potential effects from low growth rates.
This translates into an urgent need for tools capable of publication retrieval, entity recognition (including gene name, gene function, expression pattern, polymorphism and phenotype) and mapping of free text descriptions of gene function to ontology terms, with the latter representing the most severe bottleneck in our workflow.
For all three non-AF populations the null hypothesis was rejected for all of the demographic models analyzed except for JP in the case of Model 10 incorporating the most severe bottleneck.
Before crystallization, expression of sufficiently high amounts of proteins is the first severe bottleneck in structural studies of membrane proteins.
The technological development of sequencing methods has led to a situation where the interpretation of the generated data is a severe bottleneck for the use of genetic information.
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