Next we grouped together gene triplets obeying the same logic function and mapping to the same set of three complexes.
In the next step we identified multiple gene triplets that mapped to the same set of three complexes.
A small training set of six complexes was used to find the optimal values for two docking parameters, namely the number of docking trials and the percentage of restraints to discard at random (see Text S1).
Thus, a set of fifteen complexes for each lanthanide ion, with various representative ligands of high crystallographic quality (R factor < 0.05 Å), and which possess oxygen and/or nitrogen as coordinating atoms, was used as the training set.
The aerobic NMES exercise system delivers a repeating set of four complex staggered pulses at high intensities (typically 100 mA+) through an array of eight thigh electrodes.
By grouping gene triplets, we are able to decipher coordinated regulation among sets of three complexes.
Recently, the analysis of WTCCC (Wellcome Trust Case Control Consortium) data sets of seven complex disorders suggested that haplotype analyses in current GWAS can guide future re-sequencing approaches to identify underlying rare functional variants [29].
To compare the distribution of phenotypes amongst protein complexes to that expected by chance we divided the set of protein complexes into ten evenly spaced bins according to the percentage of tested subunits that shared each phenotype.
∼ 700 genes tested in pancreatic and ∼ 550 genes tested in breast We next divided the set of matched complexes M into two subsets: M ′ - those with higher co-expression in normal vis-a-vis PDAC, or higher co-expression in BRCA1 tumours vis-a-vis BRCA2 tumours; and M ″ - those with lower co-expression in normal vis-a-vis PDAC, or lower co-expression in BRCA1 tumours vis-a-vis BRCA2 tumours.
In these cases, one unit was the 'winner' during measurements with the first set of two AM tone complexes, whereas the other unit was the 'winner' during measurements with the second set of stimuli.
Step 3 (Termination or not?): If simbest is larger than 0, go to step 4; otherwise, return the current set C of clusters (with at least two proteins) as the set of predicted complexes.
