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Indeed, the bulk for the oxygen requirement centers on the sequential transformation of lanosterol to cholesterol, involving several redox reactions.
This idea, also known as the retrograde hypothesis, has intuitive appeal and states that if the contemporary biosynthesis of compound "A" requires the sequential transformation of precursors "D," "C," and "B" through the corresponding enzymes, the final product "A" of a given metabolic route was the first compound used by the primordial heterotrophs (Fig. 8).
"Lignite" ranks in between peat and subbituminous in the sequential transformation from decomposed plant matter to anthracite (Whitehurst 1978).
In addition to HPV, the sequential transformation of cervical squamous epithelium requires the acquisition of additional copies of chromosome arm 3q.
These authors were able to identify genes that are involved in the sequential transformation of normal to malignant plasma cells and thus can be useful in identifying the progression of MGUS to PCM.
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The α- and δ-relaxation times were found to be sensitive to the sequential transformations between mesophases.
The sequential transformations are (1) alkane bromination to alkyl bromide(s) and HBr, (2) reaction of this mixture with solid metal oxide (MO) to neutralize the HBr and to generate oxygenated products or olefins plus solid metal bromide, and (3) oxidation of the spent solid with O2 to regenerate the metal oxide and Br2 for reuse.
Our model can be readily extended to include the growth of the domain and study precisely this sequential transformation.
The simplest sequential transformation is retiming.
To minimize distortions due to the interpolation step in rigid transformations, one wants to reduce the number of sequential transformations for the original subtomograms.
The over-expression strain was constructed by sequential transformation of E. coli ER3081 (NEB) by pSYXS20-hpyAVM and then pAII17-hpyAVR.
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