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There are several hypotheses on the mechanism for the arrhythmogenic effect of hydrocarbons and fluorocarbons including: the effects on the central nervous system, respiratory reflexes, changes in potassium levels, or either the adrenergic and/or cholinergic receptors; the direct effects on the cardiac conduction system; or the sensitizing of the heart to the endogenous catecholamines [ 28, 37].
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The USRDS 2010 annual report confirmed the sensitizing effect of transfusions.
Apart from the similarity of the sensitizing and test stimuli, however, such "intrinsic sensitization" is mechanistically analogous to "extrinsic sensitization" in Aplysia gill withdrawal reflex [ 51].
Reminding that the PL measurements were done under non-resonant excitation, this behavior underlines the strong coupling between Si-np and Nd3+ ions, and, accordingly, the potential of sensitizing of Si-np.
Interestingly, the structure of the sensitizing model allows also simulating different cell types.
The authors review literatures reporting the role of miRNAs in sensitizing of or mediating resistance to traditional and targeted cancer therapies.
It was also found that the main site of the insulin sensitizing activity of ligand activated PPARγ was, in fact, adipose tissue [116].
Furthermore, genetic manipulation of Hsp27 expression significantly affected the TRAIL sensitizing activity of LY303511, which corroborated the Hsp27 targeting activity of LY303511.
Further study of the insulin sensitizing effects of HCQ in patients with RA is warranted.
We provide evidence that cAMP sensitizes the InsP3-sensitivity of InsP3-induced Ca2+ release in a PKA-dependent manner.
One possible explanation for the apoptosis sensitizing effects of S100A4 is that the protein positively modulates IFN-γ-signaling in general.
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CEO of Professional Science Editing for Scientists @ prosciediting.com