The importance of COG function in intra-Golgi transport and its secondary implications on glycosylation are furthermore underscored by the discovery of mutations in the genes encoding the COG1, COG7 and COG8 subunits that were linked to congenital disorders of glycosylation (CDG) (12, 14– 14).
A secondary implication of this study is that if alleles with sex-specific or sexually antagonistic effects are responsible to some degree for contributing to disease risk, then longer-term therapeutic aspirations (summarized as 'personalized medicine') will also need to take gender into account.
Also on loop ef, the shift from the conserved proline on site 266 to a leucine will alter the rigidity of the secondary structure, with implications in the protein-protein interface contacts.
When we cover the stories that day, the attention is always on the San Felipe because of its Kentucky Derby implications and the secondary story is the not-quite-as Big 'Cap.
The clinical implications of the secondary RAS mutation, including the potential efficacy of anti-EGFR antibody therapy, remain unknown.
However, very few investigations deal with the implications of the secondary structure of cpDNA repetitive elements on their origin, proliferation and potential function [ 26].
The secondary objective is to explore the potential cost implications of reducing the rate of unplanned first dialysis in Canada.
Add the secondary information.
Get the secondary weapons.
This is not only difficult because of bogging and the need to tow trucks through the area; it can also have secondary adverse implications for skidding and loading with undesirable landings and skid trails being developed to overcome the problem of the unfinished road.
During the informed consent process, it is also important to explain to the participants the implications of returning secondary/incidental findings and then to subsequently determine whether the research participants would opt to receive these results, and what their expectations are in this regard.
