Exact(1)
As the scope of screening is to lower mortality from breast cancer by introducing early diagnosis, breast cancer incidence will inevitably increase shortly after the onset of screening.
Similar(59)
The scope of prenatal screening has considerably widened last two decades.
Clearly, this demarcation of the scope of prenatal screening would require further specification.
Inevitably, this raises the question of what the scope of prenatal screening for fetal abnormalities should be.
Every effort has been made to ensure that every newborn receives quality appropriate services within the scope of the screening program [ 6].
To the extent that findings beyond the scope of the screening offer can reasonably be avoided by technical means, doing so is ethically preferable.
As argued in this document, there are strong ethical reasons for not expanding the scope of prenatal screening beyond serious congenital and childhood disorders.
Clearly, this would require redefining the scope of the screening (also in the pretest information and consent procedures) as targeting a wider range of chromosomal abnormalities than Down syndrome and other common autosomal aneuploidies.
As much as reasonably possible, it should also be discussed with them whether they would or would not want to be informed about clinically relevant findings beyond the scope of the screening offer.
With improving screening technologies and decreasing costs of sequencing and analysis, it will become possible in the near future to significantly expand the scope of prenatal screening beyond common autosomal aneuploidies.
However, the problem with forgoing those benefits for this reason is that it puts women at a higher miscarriage risk in order to maximize the detection of conditions outside the scope of the screening to which they have consented.
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