The scope of function and mechanism of action of Mups remains controversial.
A new section titled "Short length of domains, repeats and domain definitions can limit the scope of function recognition" has now been included to discuss these examples.
As seen in (Additional file 6: Table S5), for 39 domains with potential enzymatic role, short length of the query domain and alignments limited the scope of function recognition.
It is clear that the physiological roles of the genes in the putative core FeHm modulon are broad in the scope of function and may encompass most cellular processes including replication, energy metabolism, solute transport, protection against oxidation and biofilm formation.
Given this clustering of positive neural/cognitive results with sodium nitrite supplementation, future clinical trials will need to expand the scope of cognitive functions assessed and use fMRI to understand potential neural mechanisms in vivo.
However, its relatively weak mechanical properties limit the scope of applicable functions.
The introduction of digital relays has provided an unprecedented level of computational power in the substation and this has vastly increased the scope of the functions that can be delivered by any protection system.
This recursion is guided by the structure of a graph of translation tables that help compartmentalize the scope of various functions and identifier spaces, while relating these spaces for resource discovery, resolution, and routing.
Both of these methods rely on GO annotation, which may limit the scope of gene/protein functions.
Recently, studies have revealed that Tregs may also control non-immunological processes, thereby expanding the scope of Tregs functions.
