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The scope of function and mechanism of action of Mups remains controversial.
A new section titled "Short length of domains, repeats and domain definitions can limit the scope of function recognition" has now been included to discuss these examples.
As seen in (Additional file 6: Table S5), for 39 domains with potential enzymatic role, short length of the query domain and alignments limited the scope of function recognition.
It is clear that the physiological roles of the genes in the putative core FeHm modulon are broad in the scope of function and may encompass most cellular processes including replication, energy metabolism, solute transport, protection against oxidation and biofilm formation.
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The scope of functions sets OSSperf apart from the other solutions, we investigated in this work (see Table 1).
"If I didn't admit to being surprised by the scope of serotonin function, and how important it is to tissues like bone," said Patricia Ducy, who studies the effect of serotonin on bone biology at Columbia University Medical Center, "I would be lying".
A marriage of ingenuity and evolution will expand the scope of protein function well beyond Mother Nature's designs.
ClinicalTrials.gov NCT00454545 Over the past years, investigators from many scientific disciplines have demonstrated that the scope of chemokine function extends far beyond their chemoattractant moieties.
Given the emerging importance of the UPS in neurons, a logical step towards better understanding the scope of its function in neurons and at synapses would involve an examination of the neuronal targets of the UPS.
The scope of heparanase function has recently been challenged by evidence documenting its ability to activate signaling molecules (i.e., Akt, p38, Src) in an enzymatic-independent manner, resulting in enhanced gene transcription [42], [47] and cell adhesion [26] [28].
Given this clustering of positive neural/cognitive results with sodium nitrite supplementation, future clinical trials will need to expand the scope of cognitive functions assessed and use fMRI to understand potential neural mechanisms in vivo.
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