The bloks could talk to one another if they were all designed to work with the same signalling system.
For other road users (pedestrians, cyclists, etc), several warning techniques can be used in order to provide the same signalling information.
This suggests that the same signalling pathway was elicited in both cases.
We investigated if the SM-induced differentiation of spermatogonia in vitro involved the activation of the same signalling pathways.
Somitogenesis and LR patterning share the same signalling pathways that occur at overlapping developmental time windows and in nearby embryonic tissues.
Thus, an unsolved question is how the same signalling molecule can regulate such distinct cell processes as proliferation, cell survival and differentiation.
Craniofacial structures develop in close proximity with the brain, and the same signalling molecules, namely Fgfs, Wnts, BMPs and Shh, are involved in both brain and face morphogenesis [3], [4].
Therefore, by binding to Gab adaptors, YopH might target p85 or other proteins recruited to the same signalling complex that quite likely would regulate phagocytosis in the immune system.
The finding that pharmacological inhibition of ROCK mimicked the same signalling of p17Δ36, identifies the RhoA/ROCK pathway as the major target of p17-mediated signalling, and establishes for the first time that p17 activates PTEN via its COOH-terminal tail.
Endotoxaemia in the rat results in a reduction in fast-twitch skeletal muscle protein content by reducing protein synthesis [2] and increasing protein breakdown [1], but it is currently unclear if a decline in myocardial protein content also occurs under these conditions, and whether any change observed is regulated by the same signalling and genomic pathways as skeletal muscle.
These data suggest that Src kinases and RhoA/ROCK might act in the same signalling pathway.
