After this a further combination of 5000 steps of steepest descents and 5000 steps of conjugate gradients energy minimisation were carried out in which the same restraining force was applied to all backbone atoms only.
The stepwise restraint releasing strategy was used again to equilibrate the systems under NPT conditions at 1 atm and 293 K: a weak restraining force (5.0 kcal mol−1 Å−2) was applied to the whole protein over 50.0 ps, followed by a further 50.0 ps with the same restraining force applied only on all backbone atoms, and then finally 25.0 ps without any restraints.
For that to happen, however, the country would have to adopt some of the same restraining mechanisms that are in place in the European system to ration the benefit.
At the same time, restraining PKC pathway also demonstrated protection against ischemia-reperfusion injury and confer renal graft protection in rat models [ 43].
Such balance between immune activation and subsequent deactivation is critical to eliminate invading pathogens, while at the same time restraining the risk of self-destruction by unopposed inflammatory responses [ 18].
The Republican budget "fully funds our priorities and at the same time restrains the growth of the rest of government," said one member of the Budget Committee, Representative Patrick J. Toomey, Republican of Pennsylvania.
He loved not only the uproar of revolt and the noise of the club, the marketplace and the barricade; he loved the preparatory agitation, the excited and at the same time restrained life spent among conspiracies, consultations, sleepless nights, conferences, agreements, corrections of ciphers, invisible inks and secret signs".
A striking example of opposing effects is offered by TLR ligands that promote osteoclastogenesis by activating RANKL expression on stromal cells, yet at the same time restrain the amount of bone resorption by directly inhibiting early osteoclast precursors.
Separately, the states of Washington and Minnesota, which spearheaded the suit that led to the freeze of the first executive order, asked U.S. District Judge James Robart in Seattle to apply the same temporary restraining order he issued in February to the new ban.
They are also going head-to-head with Asians and central Europeans.To salvage the public finances at the same time as restraining wages or pursuing microeconomic reform may seem to be asking too much.
In a recent pamphlet Simon Tilford, of the Centre for European Reform, a London think-tank, puts the probability as high as 40%.Italy needs to reduce its massive debt and grow its economy, a very tall order.To salvage the public finances at the same time as restraining wages or pursuing microeconomic reform may seem to be asking too much.
