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We next mutated both NLS3 and NLS4 by the same mutations described above (hereafter referred to as NLS-M).
Many of them are already being developed for other types of cancer that have the same mutations.
Remarkably, the cells of participants younger than 65 were free of the same mutations, suggesting a link to the aging process, known as cellular senescence, which Dr. Attardi continued to study until recently.
Fouchier is also interested in knowing whether the same mutations can make other H5N1 strains "airborne".
Specifically, if the pig isolates are older than the human ones, they should share the same mutations, he says.
A second group of researchers from the University of Marseille in France found the same mutations in two HGPS patients.
The researchers interpreted the results as a sign that the same mutations might cause the strain to go pandemic.
Six mutant proteins were constructed with the following amino acid substitutions: D11C, S28C and D11C/S28C in hMT-2 and the same mutations in hMT-2β, respectively.
The team later found many of the same mutations in HIV from 400 other patients who were not responding to long-term retroviral therapy.
Caruso says that the researchers "make a pretty persuasive case for their conclusions," especially because the same mutations in the tested mice are also found in humans.
And once patients have that information, they could use it to find others with the same mutations and check if they have the same symptoms.
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CEO of Professional Science Editing for Scientists @ prosciediting.com