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One important implication of our findings is that the same core nanoparticles coated with different materials may display different nanotoxicity.
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However, the flexibility of RNA motifs has seldom been used to construct diverse shaped nanoparticles utilizing the same core structure.
Furthermore, only a few studies have compared cytotoxicity of QDs with the same core but different size, indicating that smaller QDs display higher toxicity than larger nanoparticles.
Both instruments share the same core items.
The core/shell nanoparticle with the core and the shell host matrix of different composition has also been investigated for the enhancement of the UC efficiency of the core nanoparticles.
This conclusion is further supported by the observation of a prolonged lifetime of UC PL at 800 nm in the core/shell nanoparticles than in the core nanoparticles (Supporting Information, Figure S8).
As one can see, the NIR UC PL at 800 nm in the core/shell nanoparticles is about 350 times higher than that of the core nanoparticles.
We also study the dry CdSe Core nanoparticles for comparison.
The Ostwald ripening process is able to dissolve energetically less stable small sacrificial nanoparticles into shell monomers, which can then deposit on the larger stable core nanoparticles.
Han et al. reported on 2 orders of magnitude enhancement of NIR-to-UV UC emission in a series of NaYF4:(20 100%)Yb3+/Tm3+@CaF2 core/shell nanoparticles when compared to the core nanoparticles.
The absolute quantum yield of the 30 nm (NaYF4 Yb3+/Er3+)@NaYF4 core/shell UCNPs is 3 times higher than that of NaYF4 Yb3+/Er3+ core nanoparticles of the same size, reaching as high as 0.3% under excitation of 150 W/cm at ∼980 nm.
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