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While the rupture rate from amniocentesis is low, the procedure is so common that a significant number of miscarriages occur.
"You will be asked to address the adequacy of the rupture rate information," she told the advisory panel.
"The British government is all hung up on the rupture rate, but that's missing the point," Dr. Mercer said.
The French government, which apparently keeps better records, says the rupture rate for the PIP devices is about 5.5 percent, more than five times the industry standard.
On Thursday, Laurent Lantieri, a well-known French plastic surgeon, said that he believed that the rupture rate was far higher than the 5 percent the French authorities have thus far indicated.
The key question will be the rupture rate of the implants.
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A spokeswoman for the French health products safety agency, known as Afssaps, said it was possible that the rupture rates in other countries were lower because reporting was still low, or because complaints had not yet reached some governments.
"The point is not so much the rupture rates but that the quality of the silicone in these implants is not of medical grade.
If objects move faster than the timescale of bond-dissociation, they are limited by the rupture rates in the system [ 297] which might explain the comparably slow movements in the spindle.
Although our study and the earlier Hedén study used the gold standard rupture detection method of MRI, the rupture rates were based on the rupture prevalence at a point in time after implantation, approximately 8 years after implantation in our study.
A limitation to the current study is that, although SA3N is a potent inhibitor of GzmB and only known inhibitor of extracellular GzmB that has been used in vivo, SA3N can also inhibit chymotrypsin, neutrophil elastase and cathepsin G. SA3N has been utilized previously in an animal model of AAA where the rupture rates and ECM remodelling was similar to that observed in using GzmB knockout mice.
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