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While some details are known about the roles of circulating EV's in the complex physiologic and pathophysiologic activities of endothelium there is much yet to be examined.
Further studies evaluating the roles of circulating monocytes in the pathogenic process of SSc should help to elucidate the complex pathophysiology of SSc and assist us to develop novel therapeutic strategies in this multisystem fibrotic disease.
Second, prominent upregulation of versican and CCL2 in circulating monocytes was observed in a minority of SSc patients, raising a possibility that the monocytic versican-mediated pathogenic process is only one of the roles of circulating monocytes in the pathogenesis of SSc.
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Specifically, the role of circulating, superinfecting virus strains is unknown.
Objective: To review the role of circulating C19 steroids as precursors of estrogens in postmenopausal women.
However the role of circulating monocyte interactions in vascular and hepatic regeneration is not well-defined.
To evaluate the role of circulating tumour cells (CTCs) in patients with endometrial cancer (EC).
To gain insight into the role of circulating catecholamines on retinal blood flow in vivo.
The role of circulating allergen-specific T cells in the pathogenesis of food-allergic skin symptoms is still under investigation.
The role of circulating CCN2 as a potential prognostic biomarker for adverse remodelling, heart failure development and long-term prognosis in STEMI patients appears to be limited.
Dr. Jeffrey's group also studies the role of circulating tumor DNA (ctDNA) in evaluating efficacy of surgical resection of metastases from colorectal cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com