Sentence examples for the role of activating from inspiring English sources

To test the role of activating IP3 receptors in PKA activation, astrocytes were treated with the IP3 receptor inhibitor 2-aminoethoxydiphenyl borate (2-APB; 5μM), 5 minutes before E2 stimulation.

The role of activating PI3KCA mutations or PTEN loss as a potential explanation for the persistent activation of PI3K signaling in lapatinib resistance remains controversial [ 19, 26- 28].

Alltogether these data suggest that KIRs may be involved in the pathogenesis of virus-induced malignancies, although the role of activating and inhibitory receptors remains unclear.

With this limitation of not having pre-treatment results, the role of activating mutations in additional oncogenes in TKI-resistance may be the primary cause for TKI resistance especially in the case of KDR Q472H mutations.

Similar neuroprotective effects mediated by several SIRT1 activators were previously demonstrated in two different EAE models of MS, relapsing/remitting EAE in SJL/J mice [ 23, 24] and chronic EAE in C57BL/6 mice [ 22], but the mechanism of these effects was not assessed beyond the role of activating SIRT1.

Although our study was not designed to investigate the role of activating ligands, analysis of the NKG2D ligands MICA/B and ULPB2 showed that most myeloma cell lines in our panel expressed at least one of these ligands (supplemental table S2).

In the last decade, it has undergone a major transformation, sparked by the landmark discovery of the central role of activating KIT mutations in its pathogenesis and recognition of KIT protein expression (CD 117) as a reliable diagnostic marker of disease.

To investigate the possible role of activating FcγR in human LN, we examined the expression of FcγRI/CD64, FcγRIII/CD16 and FcγRII/CD32 on circulating monocytes from SLE patients, and the relationship of FcγR expression levels to renal involvement and chemokine production.

Several GEFs, referred to as ROPGEFs, have been located at the apical membrane of elongating pollen tubes, where they serve the functional role of activating apically located RAC/ROPs (Gu et al. 2006; Zhang and McCormick 2007).

This suggests that the protective role of activating KIRs may be more pronounced in HL cases associated with EBV.

The proinflammatory role of activating FcγR in LN is evident in mice deficient in FcγRI/III, which are protected from the development of renal disease despite the presence of glomerular IC deposits [ 10].