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While the flower model achieves a better accuracy than the circular model, the evaluation of the results requires a numerical computation.
Adding a new batch of position weight matrices for TFBS requires computation of all genes in the database and thus requires about one month of computation.
The resulting algorithm does not require computation on any local coordinate system and is simple to implement even for an evolving manifold.
Therefore, such an approach would require computation of a large number of S2 functions, which is not only computationally intensive but also the results are difficult to interpret.
Clearly, with random order of results, the optimal result may reside in the end of the result list requiring many set distance computations for results appearing before it.
Unlike the usual Lagrangian-type computations, the resulting method requires the velocity field defined only at discrete locations.
In addition, the search for the value of that maximizes utility while operating within the energy constraint adds complexity to the optimization problem, and as a result the Lagrange implementation requires more computation than the straight knapsack solver for a single application workload.
The time frequency analysis of the FRFT's results in the EGB requires less computation and has a high resolution.
Their solution does not require the results pre-computation (signature) of all the possible queries nor deliver the whole database to the user.
However, the algorithm requires more computation time to converge.
Given the scale of the network in the study area, territorial accessibility in terms of travel time was broken down into discrete classes of 30 min as a compromise between the accuracy of the results and the computation time required.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com