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Since doxorubicin is included in most of the chemoterapeutic regimens for treatment of breast cancers, our results might also suggest that, at least in some cases, the reported relation between high cyclin E levels and poor prognosis in breast cancer patients might simply reflect the reduced responsivity of cyclin E-overexpressing tumours to doxorubicin (Keyomarsi et al, 1994; Nielsen et al, 1996).
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However, given that a false-positive finding has been excluded by the TransATAC validation dataset, this variability is most likely to reduce the strength of the reported relations.
The reported relations between phthalates and thyroid hormone make such findings biologically plausible; however, additional research is urgently needed to replicate these findings and determine the underlying etiologic mechanism.
Crucially, symbolic number-ordering ability fully mediates the previously reported relation between approximate number acuity and more complex mathematical skills, suggesting that symbolic number-ordering may be a stepping stone from approximate number representation to mathematical competence.
Conclusions: Our study is the first in human to report relation between acute changes of uremic toxin and cognition with B2M as a key player.
The observed changes in metabolite levels are discussed in relation to the reported effects of TCDD.
For the other carotenogenic enzymes, no clear relation with the reported transcriptional regulation profile was observed.
Potential mechanisms underlying the reported paradoxical adiponectin-cardiovascular risk relations were recently comprehensively and elegantly proposed by Sattar [ 73].
Although the sample size was small, the study reported a relation between nucleosome levels and disease severity but not with microorganisms or renal function [ 50].
The present pilot study is the first to report the relation between the tumour level of PMN-E and the efficacy of systemic therapy in patients with advanced breast cancer.
Despite the father's abuse, she reported "The relation to my father was even better than to my mother, to her I didn't even have one".
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