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In the meta-analysis from Di Bardino et al. US-guided biopsy was generally very well tolerated and safe, with a pooled incidence of PNX of 4.4% (22/503) in the reported papers.
We initially extracted 30,000 18-nucleotides (nt) sequences from the 200,000-nt sequences of naturally existing genome DNA strands based on the principal rule of avoiding self-dimerization of hybridization-sensitive probes, as mentioned in the reported papers [31].
Patient and tumour characteristics are available in the reported papers.
However, the testing protocol used in the reported papers is so different that such claims are difficult to verify.
It is noteworthy that in none of the reported papers foreign body reactions or infections were observed in the studied patients, regardless of the clinical application.
Given the differences in sampling in the reported papers to date, it is timely to have population-based data available of breathlessness cross-tabulated with in the community.
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