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Here, we trained networks using all data for the relevant loci, HLA-A or -B, except the data for the molecule in question (i.e. a "leave-one-out" validation, here after refereed to as Pan).
Is deacetylation of a single site (e.g., H3K18) sufficient to suppress transcription or this is because only one site is acetylated in vivo at the relevant loci?
Still, clinical diagnostic applications of sequencing where specific clinical questions need to be answered might favor analysis of only the relevant loci at high coverage.
Whether allelic variation is maintained at the relevant loci by mutation alone or by some selective advantage for asexual reproduction is not known.
Complementary expression patterns – each parent contributing alleles that show higher expression than those at the relevant loci in the other parent – could have the same effect.
As the genetic architecture of these diseases continues to be revealed, such prediction may become feasible, and knowledge of the imprinting status of the relevant loci is likely to be an important component of building accurate risk models.
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Representing each HLA locus molecule, we trained a neural network ensemble using all available data for the relevant locus, excluding all data specific for the HLA allele in question.
For cases in which, despite the known presence of a gDNA locus, no matching cDNA was detected, the relevant locus was scored as "silenced".
The gene was discovered in 1997 as the relevant locus on a region of chromosome 10 that is deleted in multiple advanced cancers.
Genome-wide or more focused screens for disease-associated alleles assume that any gene products involved in a pathogenic process will be encoded at polymorphic loci such that some, but not all, allelic products at the relevant locus or loci will be participants in the disease process (or at least will be substantially more contributory than alternative alleles).
The mechanically relevant loci found provide the first hints at what microstructural properties might explain the variations in deformation under mechanical load.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com