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Assuming independence, the risk expressed in breast-years would be twice as high as in breast cancer survivors only one breast is at risk for CBC and the reference incidence rates concern cancer in any of two breasts.
We then calculated the number of iNTS cases for each country by using the reference incidence rates from the cell, according to the assignment of each country in the matrix and each country's population stratified by age groups.
Follow-up did not stop at the date of first diagnosis of cancer, and so all primary cancers diagnosed during the follow-up were counted as observed cases and included in the reference incidence rates.
If a matrix cell had >1 data source after the iNTS incidence data were assigned, the mean incidence from all sources was calculated as the reference incidence for that matrix cell.
The capital cities of these northernmost and southernmost states are located at 27.5º south and 42.9º south, respectively (table 1). Figure 1 shows the pattern of risk for multiple sclerosis for each two month period of birth, expressed as an incidence rate ratio for each period of birth relative to the reference incidence rate ratio (1.0) for May-June.
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Using atorvastatin, the most widely prescribed statin in Japan, as the reference, incidences of muscle toxicity were statistically indistinguishable among the statins, regardless of the criterion used.
This study aimed to have at least 300 patients receive the second rituximab infusion at a faster rate so that an increase of at least 3%to4%4% of IRRs from the weighted reference incidence (8% to 9%, based on historical data for rituximab) would be statistically significant.
Australian and UK age-specific cancer incidences were used as the population reference incidences, based on the recent update of the BOADICEA model that incorporates calendar period cancer incidences up to 2010 and country-specific incidences.
Most studies modeled the prescreening incidence trend through the study period to determine reference incidence, though this assumes that incidence would have continued at the same rate without non-linear changes.
Otherwise known as rate multipliers, IRRs indicate the relative impact of a covariate on a reference incidence rate, here represented by the estimated intercept (which reports the incidence rate of drug utilization per 100,000 individuals).
Expected numbers of cases for each block group were computed by applying reference incidence rates for the same years (as estimated from the four administrative departments of the study area, plus the departments of Doubs and Hérault) to the person-years of each area stratified by gender and 5-year age classes.
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